Abstracts
International Journal of Clinical Nutrition (IJCN) ISSN (India) 0971-9210, Url: https://ijcnworld.com/
A publication of the International College of Nutrition,
2011; Vol 11(1): 1-25
FIBROMYALGIA SYNDROME: NUTRITIONAL INTERVENTIONS AND MANAGEMENT
Ghizal Fatima1, Ammar Mehdi Raza2, Najah Hadi3, Afroz Abidi4
1Department of Biotechnology, Era University, Lucknow, India
2Department of Paedodontics, Career Dental College and Hospital, Lucknow, India
3Department of Medicine, Kufa University, Kufa, Iraq
4Department of Pharmacology, Era University, Lucknow, India
Correspondence:
Dr. Ghizal Fatima
Department of Biotechnology,
Era University, Lucknow, India
Abstract
Fibromyalgia syndrome (FMS) is a multi-factorial syndrome of unknown etiology, it is characterized by widespread pain, various psychological and somatic manifestations. In the management of FMS a multidisciplinary approach combining both pharmacological and non-pharmacological strategies are required. (1) In non-pharmacological management, vast evidence suggests a potential beneficial role for nutrition. This paper summarizes the possible amalgamation in between nutrition and FMS, however, exploring the available evidence on the effect of dietary supplements and also the dietary interventions in FMS patients. Literature analysis has depicted that the role of dietary supplements still remains controversial, although clinical trials done with vitamin D, iron, magnesium and probiotics’ supplementation showed promising results in its management. (2) Furthermore, in dietary interventions, the supplementation of olive oil, the replacement diet with ancient grains, the gluten-free diet, low-calorie diets, the low FODMAPs diet, the monosodium glutamate diet and also the aspartame-free diet, vegetarian diets as well as the Mediterranean diet all appear to be equally effective and important in reducing the symptoms severity in patients with FMS. Moreover, these results may conclude that weight loss, along with the psychosomatic component of the disease, should be taken into account. Therefore, although dietary aspects appear to be a promising complementary approach in treating the patients of FMS, further research is needed to provide the most effective strategies for the management of FMS.
Key words: Nutrition, management,fibromyalgia, psychosomatic
How to cite: Fatima G, Ammar Mehdi Raza, Najah Hadi, Afroz Abidi Fibromyalgia Syndrome: Nutritional Interventions and Management. Int J Clin Nutrition. 2011; 11(1): 1-5.
References:
1-Abbas Ali Mahdi, Ghizal Fatima. A Quest for Better Understanding of Biochemical Changes in Fibromyalgia Syndrome. Indian Journal of Clinical Biochemistry, 2014, Volume 29, Issue 1, pp 1-2.
2- Sidrah Parvez, Ghizal Fatima*, Wajdy Al-awaida, Yasmeen Ali Hussien, Sara Al tamam & Najah Hadi. Vitamin D: Implications in COVID-19. Lat. Am. J. Pharm. 40 (special issue): 23-6 (April 2021) ISSN 2362-3853.
NUTRITIONAL SUPPLEMENTATION AND FIBROMYALGIA
Natalia Vaňova1, Najah Hadi2, Ghizal Fatima3, Ram B. Singh4
1Clinic of Internal medicine University of Pavol Jozef Šafarik, Košice and Hospital Agel Košice Šaca, Slovakia, Lúčna 57, 04018 Košice-Šaca nvanova@nke.agel.sk
2Department of Medicine, Kufa University, Kufa, Iraq
3Department of Biotechnology, Era University, Lucknow, India
4Department of Medicine, Halberg Hospital and Research Institute, Moradabad, Lucknow, India
Correspondence:
Dr. Natalia Vaňova
Clinic of Internal medicine, University of Pavol Jozef Šafarik,
Košice and Hospital Agel Košice Šaca,
Slovakia, Lúčna 57, 04018 Košice-Šaca nvanova@nke.agel.sk
Abstract:
Imbalance in the dietary components in patients with FMS, including minerals and vitamins, can play a critical role in the development of the disease. In a survey conducted by Arranz and colleagues (1) revealed that 74% of the patients affected by FMS uses nutritional supplements for their health, and 60% of these FMS patients became users of these supplements after the onset of FMS. However, a recent meta-analysis revealed a small evidence to support the hypothesis that vitamin and mineral deficiencies may play a pertinent role in the development of FMS, or that the use of any nutritional supplements by these patients could be effective (2). Some evidence suggests that vitamin D supplementation should be considered in the management of FMS in light of the fact that about 40% of FMS subjects have been reported with vitamin D deficiency (3). Regarding the mineral status, several studies have shown a decrease in intracellular magnesium content in FMS patients (4). Magnesium deficiencies were largely associated with low-grade inflammation, muscle weakness and paresthesia, which are typical symptoms of FMS (5). A recent study has shown that low dietary magnesium intake is correlated with worsening pain threshold parameters in FMS patients. Several dietary approaches have been proposed with the aim of reducing the symptomatology of FMS. Therefore, although dietary aspects appear to be a promising complementary approach to treat FM, further research is needed to improve the understanding of the disease and to provide the most effective strategies for managing FM syndrome.
Key words: Nutrition, Supplementation, Fibromyalgia, vitamin D
References:
1- Pandey CM, Chauhan A K, Tripathi R. Nutritional management of severe mal-nutrition. Int J Clin Nutrition 2007; 7: 1-5.
2- Ghizal Fatima, Ammar Mehdi Raza, Najah Hadi, Afroz Abidi. Fibromyalgia Syndrome: Nutritional Interventions and Management. International Journal of Clinical Nutrition. 2011, Volume 11(1) 3-4-2.
3- Sidrah Parvez, Ghizal Fatima, Siddharth Kumar Das, Israr Ahmad. Positive and negative association of vitamin d with Fibromyalgia Syndrome. Era’s Journal of Medical Research. DOI:10.24041/ejmr2020.21.VOL-7.
4- Darlenska TH, Kuzeva A, Handjiev S. The role of bee products in the prevention and treatment of cardiometabolic disorders. Int J Clin Nutrition 2010; 10: 1-5.
5- Singh M, Chibisov S, Singh RB, Halabi G, Horiuchi R, Takahashi T. Nutritional prevention of obesity and metabolic syndrome. In J Clin Nutrition 2010; 10: 6-10.
How to cite: Natalia Vaňova, Najah Hadi, Ghizal Fatima, Ram B. Singh. Nutritional Supplementation and Fibromyalgia. International Journal of Clinical Nutrition. 2011, Volume 11(1) 3-4-2.
IS DEFICIENCY OF MAGNESIUM, CALCIUM AND VITAMIN D A RISK IN FIBROMYALGIA SYNDROME?
Rana Majeed Hameed1, Ghizal Fatima2, Jan Fedacko3
1Department of Biochemistry, College of Medicine, University of Karbala, Iraq
2Department of Biotechnology, Era University, Lucknow, India
3Department of Internal Medicine, Centre of Excellence in Atherosclerosis Research, Pavol Jozef Safarik University, Kosice, Slovakia janfedacko@hotmail.com
Correspondence:
Dr. Rana Majeed Hameed
Department of Biochemistry, 7
College of Medicine, University of Karbala, Iraq
ranamajeed81@gmail.com
Abstract:
Fibromyalgia (FM) is a complex, multifactorial syndrome characterized by widespread chronic pain and a constellation of somatic and psychological manifestations, including fatigue, joint stiffness, sleep disorders, depression, anxiety, gastrointestinal and cognitive disorders [1]. The majority of studies on Magnesium, calcium and vitamin-D showed a significant improvement in chronic pain, anxiety, depression, cognitive function, sleep pattern and gastrointestinal symptoms. In addition, weight loss seems to be associated with both reduced inflammation and improved quality of life in FM subjects, thus suggesting that body weight could have a functional repercussion in these patients. Therefore, the fact that the improvement has been achieved through different dietary strategies may lead to the hypothesis that both weight loss and the psychosomatic component of the disease could have a major role in the disease. In addition, all of these diets are generally regarded as healthy dietary models, rich in plant foods, antioxidants or fiber, so the fact that people have experienced an improvement in symptoms after almost all dietary interventions suggests that an adequate diet could play a crucial role in the management of FM. However, these results should be interpreted with caution since the aforementioned studies present several biases that limit the robustness of the findings. First of all, most studies have a limited sample size with no possibility of blinding due to the nature of dietary intervention trials. Secondly, outcomes are often analyzed using different methodologies and without considering possible confounding factors. In addition, adherence to the assigned dietary intervention is hardly ever evaluated. Finally, a follow-up is almost never carried out to determine whether the positive effects are maintained over time or are only transient. Therefore, although dietary aspects appear to be a promising complementary approach to treat FM, further research is needed to improve the understanding of the disease and to provide the most effective strategies for managing FM syndrome. (2)
Key words: Deficiency, Magnesium, Calcium, Vitamin D, Fibromyalgia Syndrome
References:
1-Ghizal Fatima Siddharth Kumar Das Abbas Ali Mahdi Some oxidative and antioxidative parameters and their relationship with clinical symptoms in women with Fibromyalgia Syndrome. Int J Rheum Dis. 2015 Jul 14. 39-45.
2- Natalia Vaňova, Najah Hadi, Ghizal Fatima, Ram B. Singh. Nutritional Supplementation and Fibromyalgia. International Journal of Clinical Nutrition. 2011, Volume 11(1) 3-4.
How to cite:: Rana Majeed Hameed, Ghizal Fatima, Jan Fedacko. Is Deficiency of Magnesium, Calcium and Vitamin D a risk in Fibromyalgia Syndrome? International Journal of Clinical Nutrition. 2011, Volume 11(1) 5-6
MEDITERRANEAN DIET AND FIBROMYALGIA SYNDROME
Wajdy Al Awaida1, Ram B. Singh2, Ghizal Fatima3, Ammar Mehdi Raza4
1Department of Biology and Biotechnology, American University of Madaba, Madaba, Jordan,
2Department of Medicine, Halberg Hospital and Research Institute, Moradabad, Lucknow, India
3Department of Biotechnology, Era University, Lucknow, India
4Department of Paedodontics, Career Dental College and Hospital, Lucknow, India
Correspondence:
Dr. Wady Al-Awaida
Department of Biology and Biotechnology
American University of Madaba,
Madaba, Jordan w.alawaida@aum.edu.jo
Abstract:
Very little evidence is available on the possible beneficial effects of the Mediterranean diet on FMS patients. A recent cross-sectional study of 95 FMS patients revealed that adherence to the Mediterranean diet was consistently amalgamated with the quantitative calcaneal ultrasound parameters, supporting the hypothesis that adherence to the Mediterranean diet may play a vital role in bone health in FMS women [1]. On the other hand, a recent study of 22 FMS patients revealed that a 16 week Mediterranean diet with or without high doses of magnesium and tryptophan led to several beneficial effects on emotional processing, like decreased fatigue, anxiety and depression, and reduced possible eating disorders and body image dissatisfaction, with significant greater improvements especially in the Mediterranean diet plus supplements group. Furthermore, alterations in the intestinal bacterial flora appear to be a contributing factor in many chronic inflammatory and degenerative diseases, including rheumatic diseases such as FMS, Michalsen and colleagues have tested the effect on the gut microbiota of interventions with the Mediterranean diet and a modified intermittent 8 day fasting regimen in 35 patients affected by Fibromyalgia [2]. Surprisingly, after 2 weeks and 3 months of follow-up, the authors found no significant changes in fecal bacteria counts following the two dietary interventions within and between groups. In addition, no significant differences appeared in the analysis of secretory immunoglobulin A or the symptomatology, suggesting that neither Mediterranean diet nor fasting treatments influenced the gut microbiota or symptoms in FMS patients [2]. Therefore, although dietary aspects appear to be a promising complementary approach to treat FM, further research is needed to improve the understanding of the disease and to provide the most effective strategies for managing FMS syndrome.
Key words: Mediterranean Diet, Fibromyalgia Syndrome, magnesium, tryptophan, supplements
References:
1- Singh RB, Rastogi SS, Niaz MA, Buttar HS, Fatima G, Global relevance of
functional foods security for health promotion and disease prevention. IJCN 2022; 22(1): 1-6.
2- Michalsen A., Riegert M., Lüdtke R., Bäcker M., Langhorst J., Schwickert M., Dobos G.J. Mediterranean diet or extended fasting’s influence on changing the intestinal microflora, immunoglobulin A secretion and clinical outcome in patients with rheumatoid arthritis and fibromyalgia: An observational study. BMC Complement. Altern. Med. 2005;5:22. doi: 10.1186/1472-6882-5-22.
How to cite: Wajdy Al Awaida, Ram B. Singh, Ghizal Fatima, Ammar Mehdi Raza.
Mediterranean Diet and Fibromyalgia Syndrome. International Journal of Clinical Nutrition. 2011, Volume 11(1) 6-7
ROLE OF MAGNESIUM IN FIBROMYALGIA SYNDROME
Jan Fedacko1, Ghizal Fatima2, Najah Hadi3
1Department of Internal Medicine, Centre of Excellence in Atherosclerosis Research, Pavol Jozef Safarik University, Kosice, Slovakia janfedacko@hotmail.com
2Department of Biotechnology, Era University, Lucknow, India
3Department of Medicine, Kufa University, Kufa, Iraq
Correspondence:
Najah Hadi
Department of Medicine,
Kufa University,
Kufa, Iraq
Abstract:
Fibromyalgia Syndrome (FMS) is a common chronic pain disorder. It is the third most common rheumatic disorder after low back pain and osteoarthritis. FMS exhibits an immense burden at the individual and the society levels. Daily living activities of an individual can be profoundly impacted by FMS. The underlying etiology for FMS remains obscure.(1) While genetic and hormonal factors among others are thought to play a role in FMS patients, central sensitization is considered to be the main mechanism. (2) Magnesium is known to play an important role in the prevention of central sensitization by blocking N-methyl-D-aspartate (NMDA) receptors in a voltage-dependent manner. Magnesium deficiency has been largely associated with muscle pain along with fatigue, sleep difficulties, and anxiety; all of which are common symptoms of FMS. In some studies, it is thought that magnesium deficiency, through reductions in muscle ATP levels, may play a role in the development of FMS. (3) Other studies correlate increased levels of substance P (a neurotransmitter known for its role in pain perception) with magnesium deficiency as well as pain intensity in FMS, raising the question of a possible correlation between magnesium deficiency and FMS. (4-5) while some estimates suggest that about half of the population in the United States consume inadequate amounts of magnesium, studies have shown that magnesium is one of the most widely used supplements by fibromyalgia patients. At the Mayo Clinic FMS treatment program, 2 studies (years 2003, 2017) were performed to evaluate the frequency and pattern of complementary and alternative medicine (CAM) use in FMS patients. Both studies found that magnesium was one of the most frequently used supplements in FMS. This review aims to explore and summarize the possible relationship between magnesium and FMS in the literature and hence determine the validity of magnesium use in FMS.
Key words: Magnesium, Fibromyalgia Syndrome, symptoms, severity, supplement
References:
1-Abbas Ali Mahdi, Ghizal Fatima. A Quest for Better Understanding of Biochemical Changes in Fibromyalgia Syndrome. Indian Journal of Clinical Biochemistry, 2014, Volume 29, Issue 1, pp 1-2.
2- Ghizal Fatima Siddharth Kumar Das Abbas Ali Mahdi Nar Singh Verma Faizan Haider Khan,Baby Anjum. Evaluating relationship in cytokines level and Fibromyalgia Impact Questionnaire Revised with Body Mass Index in women with Fibromyalgia Syndrome. J Back Musculoskelet Rehabil. 2015 Jul 6. 145-9.
3- Rana Majeed Hameed, Ghizal Fatima, Jan Fedacko. Is Deficiency of Magnesium, Calcium and Vitamin D a risk in Fibromyalgia Syndrome?
4- Onsaard E, Takahashi T, Manal MA, Elkilany G, Hristova K, Moshiri K. The concept of
functional foods and functional farming: (4f) in the disease prevention and health promotion. IJCN 2022; 22,1: 28-33.
5- Becker S, Schweinhardt P.Dysfunctional neurotransmitter systems in fibromyalgia, their role in central stress circuitry and pharmacological actions on these systems. Pain Res Treat. 2012;2012:741746. doi:10.1155/2012/741746
How to cite: Jan Fedacko, Ghizal Fatima, Najah Hadi. Role of Magnesium in Fibromyalgia Syndrome. International Journal of Clinical Nutrition. 2011, Volume 11(1) 6-7